Table 2.
Tuberculosis incidence density stratified by clinical and immunological characteristics of PLHIV on chronic HIV care at Debre-Markos Referral Hospital from January 1, 2014 to December 31, 2018 (N = 494)
| Characteristics | Frequency (n = 494) | Percent (%) | Person year | TB (n = 62) | Censored (n = 432) | TB IR per 100 PY (95% CI) |
|---|---|---|---|---|---|---|
| Past TB treatment | ||||||
| Yes | 14 | 2.83 | 36.14 | 6 | 8 | 16.60 (7.46, 36.95) |
| No | 480 | 97.17 | 964.08 | 56 | 424 | 5.81 (4.47, 7.55) |
| Baseline WHO clinical staging | ||||||
| Stage I | 219 | 44.33 | 396.81 | 7 | 212 | 1.77 (0.84, 3.70) |
| Stage II | 124 | 25.10 | 294.67 | 6 | 118 | 2.04 (0.91, 4.53) |
| Stage III | 122 | 24.70 | 263.23 | 37 | 85 | 14.06 (10.18, 19.40) |
| Stage IV | 29 | 5.87 | 45.51 | 12 | 17 | 26.37 (14.97, 46.43) |
| Baseline CD4 count (cells/μl) | ||||||
| < 50 | 38 | 7.69 | 79.93 | 15 | 23 | 18.77 (11.31, 31.13) |
| 50 – < 100 | 51 | 10.32 | 95.09 | 18 | 33 | 18.93 (11.93, 30.04) |
| 100–200 | 75 | 15.18 | 170.31 | 14 | 61 | 8.22 (4.87, 13.88) |
| 201–350 | 123 | 24.90 | 268.43 | 10 | 113 | 3.73 (2.00, 6.92) |
| ≥ 350 | 207 | 41.90 | 386.46 | 5 | 202 | 1.29 (0.54, 3.11) |
| Baseline hemoglobin level (g/dl) | ||||||
| < 10 | 135 | 27.33 | 257.82 | 52 | 83 | 20.17 (15.37, 26.47) |
| ≥ 10 | 359 | 72.67 | 742.41 | 10 | 349 | 1.35 (0.72, 2.50) |
| Baseline body mass index (kg/m2) | ||||||
| < 18.5 | 161 | 32.59 | 288.03 | 47 | 114 | 16.32 (12.26, 21.72) |
| ≥ 18.5 | 333 | 67.41 | 712.19 | 15 | 318 | 2.11 (1.27, 3.49) |
| Baseline functional status | ||||||
| Working | 392 | 79.35 | 832.36 | 15 | 377 | 1.80 (1.09, 2.99) |
| Ambulate/bedridden | 102 | 20.65 | 167.86 | 47 | 55 | 28.00 (21.04, 37.27) |
| Past opportunistic infection (OIs) | ||||||
| Yes | 79 | 15.99 | 215.17 | 18 | 61 | 8.37 (5.27,13.28) |
| No | 415 | 84.01 | 785.05 | 44 | 371 | 5.60 (4.17, 7.53) |
| ART adherence | ||||||
| Good | 367 | 74.29 | 763.97 | 15 | 352 | 1.96 (1.18, 3.25) |
| Fair/poor | 127 | 25.71 | 236.25 | 47 | 80 | 19.89 (14.95, 26.48) |
| Took IPT during follow up | ||||||
| Yes | 195 | 39.47 | 406.90 | 5 | 190 | 1.23 (0.51, 2.95) |
| No | 299 | 60.53 | 593.32 | 57 | 242 | 9.61 (7.41, 12.45) |
| Total year of follow up | ||||||
| ≤ 1 year | 169 | 34.21 | 73.98 | 43 | 126 | 58.13 (43.11, 78.37) |
| > 1 - < 3 years | 180 | 36.44 | 353.47 | 11 | 169 | 3.11 (1.72, 5.62) |
| 3–5 years | 145 | 29.35 | 572.78 | 8 | 137 | 1.39 (0.69, 2.79) |