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Representative example of CD4+, CD8+, and FOXP3+ tumor-infiltrating lymphocyte and PD-L1+ immune cell infiltration in pure ductal carcinoma in situ. CD4+ (a), CD8+ (b), and FOXP3+ tumor-infiltrating lymphocytes (c) and PD-L1+ immune cells (d) are predominantly found in the peri-tumoral specialized stroma around the involved ducts and are detected in rare numbers within tumor cell nests
