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. 2020 Mar 26;22:32. doi: 10.1186/s13058-020-01267-w

Fig. 2.

Fig. 2

Representative example of CD4+, CD8+, FOXP3+ tumor-infiltrating lymphocytes and PD-L1+ immune cell infiltration in in situ and invasive components in a hormone receptor-negative tumor. CD8+ tumor-infiltrating lymphocyte (TIL) and PD-L1+ immune cell (IC) infiltration is significantly higher in the invasive component compared to the in situ component while CD4+ TIL infiltration is high in both components with no significant difference. FOXP3+ TILs are rarely found in both invasive and in situ components in this case