Table 3.
Comparison of immune cell subset infiltration in pure ductal carcinoma in situ and invasive carcinoma
| Hormone receptor status | Immune cell subset | Pure DCIS (n = 231) | Invasive carcinoma (n = 359) | p value |
|---|---|---|---|---|
| Total | CD4+ TIL | 19.3 (4.0–47.8) | 85.5 (41.0–176.5) | < 0.001 |
| CD8+ TIL | 12.3 (5.3–25.0) | 91.5 (42.0–199.3) | < 0.001 | |
| FOXP3+ TIL | 0 (0–1.0) | 9.0 (4.0–19.0) | < 0.001 | |
| PD-L1+ IC | 34/221 (15.4) | 153/350 (43.7) | < 0.001 | |
| Positive | CD4+ TIL | 17.0 (3.7–43.3) | 79.0 (38.3–152.0) | < 0.001 |
| CD8+ TIL | 11.7 (5.3–22.0) | 68.5 (34.0–139.3) | < 0.001 | |
| FOXP3+ TIL | 0.0 (0.0–0.0) | 6.5 (3.0–16.8) | < 0.001 | |
| PD-L1+ IC | 26/196 (13.3) | 72/242 (29.8) | < 0.001 | |
| Negative | CD4+ TIL | 35.0 (18.0–86.5) | 125.0 (48.8–209.3) | < 0.001 |
| CD8+ TIL | 22.7 (9.2–48.8) | 160.0 (81.8–278.3) | < 0.001 | |
| FOXP3+ TIL | 1.0 (0.0–5.0) | 15.0 (7.0–28.0) | < 0.001 | |
| PD-L1+ IC | 8/25 (32.0) | 81/108 (75.0) | < 0.001 |
For CD4+, CD8+ and FOXP3+ TILs, p values were calculated by the Mann-Whitney U test, and data are presented as median (interquartile range)
For PD-L1+ IC, p values were calculated by chi-square or Fisher’s exact test, and data are presented as frequency (%)
TIL tumor-infiltrating lymphocyte, IC immune cell, DCIS ductal carcinoma in situ