Fig. 4.

Flowchart of analyses in the Generation Scotland and Lothian Birth Cohorts. Methylation profiling in Generation Scotland was carried out in two separate sets. DNA methylation outliers were calculated within each set. Analyses were then carried out on a combined dataset. In the Lothian Birth Cohorts of 1921 and 1936, DNA methylation outliers were calculated within each wave of data collection. Analyses were carried out in the LBC1921 and the LBC1936 separately. Results from the survival analyses in both cohorts were meta-analysed