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. 2020 Mar 17;13:2311–2317. doi: 10.2147/OTT.S235882

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© 2020 Hua et al.

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Dynamic changes following the infusion of anti-CD22 and -CD19 cells within 25 days: (A) IL-6 reached peak level on day 17 and returned to normal on day 20 after infusion. IL-10 level was basically normal in the whole course; (B) C-reactive protein rapidly decreased from 92mg/mL to normal, then increased to 44.2 mg/mL on day 15; (C) During the first 15 days, BNP gradually increased to peak level; (D) Expansion of anti-CD22 and anti-CD19 CAR T cells in the peripheral blood after infusion. Genomic DNA copies increased to peak level on day 15.