Table 1.

Hematological and Clinical Parameters of Patients With SCD and Controls.^a

	Before HU Therapy	After 1 Year	Percentage of Changes	Control Healthy	P Valueb	P Valuec	P Valued
	N = 35	N = 35		N = 20
Laboratory and hematological parameters
Hb (g/dL)	7.06 ± 0.87	10.04 ± 1.35	29.70%	11.91 ± 0.64	.0001	.0001	.0001
%Hb F	7.11 ± 1.33	13.89 ± 3.57	48.80%	–	<.0001	–	–
%HbS	80·9	74·6	7.80%	–	<.0001	–	–
RBCs (1012/L)	2.45 ± 0.5	3.33 ± 0.73	26.40%	4.43 ± 0.62	.002	.0001	.0001
Hematocrit	22.79 ± 4.66	33.13 ± 6.91	31.20%	38.99 ± 5.8	.0001	.0001	.011
Platelets (109/L)	315.2 ± 91.6	290.9 ± 65.9	7.70%	271.2 ± 65.2	.649	.243	.669
WBCs (109/L)	11.35 ± 2.72	8.92 ± 2.3	21.40%	6.4 ± 2.34	.028	.0001	.006
Monocytes (109/L)	0.284 ± 0.082	0.234 ± 0.085	17.60%	0.202 ± 0.099	.313	.049	.514
Neutrophils (109/L)	5.95 ± 2.78	4.44 ± 2.27	25.30%	3.38 ± 1.67	.171	.008	.293
Total lymphocytes (109/L)	4.16 ± 0.18	3.16 ± 0.35	24%	3.06 ± 0.29	.0001	.0001	.570
Proinflammatory cytokines
hs-CRP (mg/L)	4.14 ± 1.29	3.61 ± 1.25	12.80%	1.65 ± 0.82	.15	<.0001	<.0001
IL-6 (pg/mL)	14.45 ± 3.94	11.42 ± 5.03	21%	6.67 ± 2.93	.001	<.0001	.001
IL-8 (Pg/mL)	18.43 ± 5.86	16.70 ± 4.52	9.30%	6.24 ± 3.07	.11	<.0001	<.0001
TNF-α (pg/mL)	12.71 ± 4.22	9.20 ± 1.66	27.5%	4.75 ± 2.53	<.0001	<.0001	<.0001
Clinical variables
VOC event/year	1.84 ± 1.58	0.91 ± 1.47	50.5%	–	.0014	–	–
ACS event/year	0.35 ± 0.48	0.08 ± 0.28	77%	–	.004	–	–

Abbreviations: ACS, acute chest syndrome; Hb, hemoglobin; HbF, fetal hemoglobin; HbS, hemoglobin S; hs-CRP, high-sensitivity C reactive protein; HU, hydroxyurea; RBCs, red blood cells; SCD, sickle cell disease; TNF-α, tumor necrosis factor α; VOC, vaso-occlusive crisis; WBCs, white blood cells.

^a P values were calculated using the Mann-Whitney test.

^b Baseline versus treated patients with SCD.

^c Baseline versus healthy control

^d Treated versus healthy control.