Pierrugues 1989.
Methods | Randomised clinical trial. | |
Participants | Twenty‐nine patients were included in the study (17 males and 12 females, mean age 45.8 years ± 11) with alcoholic hepatitis, 14 in the PTU group and 15 in the placebo group. Diagnostic assessment: alcoholic hepatitis with liver biopsy. |
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Interventions | Experimental group:
PTU 300 mg/day orally. Control group: placebo. Duration of treatment: 28 days. |
|
Outcomes | All‐cause mortality. Biochemistry. Liver histology. Thyroid function. | |
Notes | Sent letter in 2001. No reply. Only published as abstract. A composite clinical and laboratory index was used to evaluate the effect of PTU, but details on which index that was used are not given. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Selective reporting (reporting bias) | Low risk | All the important outcomes were reported. |
Free of academic bias | Low risk | Comment: No previous trial of the same comparison by the same authors was identified. |