Table 7.

Tissue TDGA Toxicokinetic Parameter Estimates Following Dermal Application of CEM to F344 Rats and B6C3F1 mice^a

Parameter	Heart		Thymus		Liver
	400 mg/kg		400 mg/kg		400 mg/kg
Male F344 Rats
Cmax (observed) (μg/g)	3.35		5.47		84.4
Tmax (observed) (min)	360		480		360
Half-life (min)	422		853		296
Female F344 Rats
Cmax (observed) (μg/g)	6.80		11.0		123
Tmax (observed) (min)	360		480		480
Half-life (min)	548		652		373
	Heart		Thymus		Liver
	300 mg/kg	600 mg/kg	300 mg/kg	600 mg/kg	300 mg/kg	600 mg/kg
Male B6C3F1 Mice
Cmax (observed) (μg/g)	0.731	3.12	2.35	10.0	48.2	88.2
Tmax (observed) (min)	180	240	180	480	90	120
Half-life (min)	448	169	746	542	140	145
Female B6C3F1 Mice
Cmax (observed) (μg/g)	0.833	2.64	2.94	6.76	56.9	93.4
Tmax (observed) (min)	240	240	240	480	90	120
Half-life (min)	340	218	447	300	133	140

^aBased on a non-compartmental analysis.