Table 4.
List of Chemical Groups That Displayed a Relatively High Activity in Figures 3 and 4 and the Targets That Are Affected
| Chemical Group | Target Family and Key Targetsa |
|---|---|
| Ester-aliphatic alcohol diester/triester (group 33, n = 11 of which 1 chemical is part of the regulatory restricted group) | Nonsteroidal nuclear receptor: NR1I2 (33), PPARG (22), NR1H4 (20) |
| Metallic salts organic (group 90, n = 7 of which 1 chemical is part of the regulatory restricted group) | Nonsteroidal nuclear receptor: NR1I2 (36), RXRA (33), PPARG (30) |
| Retinol derivatives (101, n = 3) | Nonsteroidal nuclear receptor: NR1I2 (45), RXRA (40), RXRB (30), VDR (25), NR1H2|NR1H3 (20) |
| Organosulfur. thiol (group 93, n = 6) | DNA binding: TCF7|TCF7L2|LEF1|TCF7L1 (60), IRF1 (40), FOS|JUN, (33), SMAD1 (33), USF1 (33), NFKB1 (33), NFE2L2 (33), POU2F1 (33), TP53 (33), AHR (28), SREBF1 (20), HSF1 (20), XBP1ng (20) |
a
Only the targets with more than 20% activity are displayed.