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Representative concentration-dependent effects on 2′-deoxycytidine metabolism in hiPSC-CM following cardiotoxicant exposure. 2′-Deoxycytidine (◆) and cell viability (●) are shown for (A) daunorubicin, (B) clozapine, and (C) pergolide. The x-axis is the drug concentration (µM) and the y-axis is the solvent control-normalized (fold change) value for 2′-deoxycytidine or cell viability. Data represent mean ± SEM (n = 3). If not shown, error bars are smaller than the size of the symbol.
