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. 2013 Jun 11;2013(6):CD002116. doi: 10.1002/14651858.CD002116.pub2

1.1. Analysis.

Comparison 1 DRUG VERSUS PLACEBO, Outcome 1 Number of people failing to achieve full continence.

Number of people failing to achieve full continence
Study Drug Placebo Significance
Loperamide versus placebo
Hallgren 1994 # 3/28 during the day
 1/28 during the night 7/28 during the day
 11/28 during the night  
Sun 1997 # 4/11 in 24 hours
 (loperamide oxide) 8/11 in 24 hours P < 0.05
Diphenoxylate + atropine versus placebo
Harford 1980 # 0/15 in 24 hours 3/15 in 24 hours  
Phenylephrine gel versus placebo
Carapeti 2000b # 8/12 12/12  
Sodium valproate versus placebo
Kusunoki 1990 # 3/17 10/17