1.4. Analysis.

Comparison 1 DRUG VERSUS PLACEBO, Outcome 4 Frequency of defecation (per day).

Frequency of defecation (per day)
Study	Drug	Placebo	Significance
Loperamide versus placebo
Hallgren 1994 #	N 28 mean 4.24 (SD 1.86)	N 28 mean 6.43 (SD 1.99)
Read 1982 #	N 26 mean 1.6 (range 1‐6.3)	N 26 mean 2.4 (range 0‐7.7)	P < 0.001 Wilcoxon's rank sum test for paired data
Sun 1997 #	N 11 mean 1.43 (SD 1) (loperamide oxide)	N 11 mean 2 (SD 1)	P < 0.02
Diphenoxylate + atropine versus placebo
Harford 1980 #	N 15 mean 2.6 (SD 2.71)	N 15 mean 4.9 (SD 3.1)
Sodium valproate versus placebo
Kusunoki 1990 #	N 17 mean 5.98 (SD 2.97)	N 17 mean 9.65 (SD 3.59)