1.8. Analysis.
Comparison 1 DRUG VERSUS PLACEBO, Outcome 8 Number of people with adverse effects.
| Number of people with adverse effects | ||
|---|---|---|
| Study | Drug | Placebo |
| Loperamide versus placebo | ||
| Read 1982 # | 18/26 (constipation 11, diarrhoea 4, nausea and vomiting 3, abdominal pain 2) | 1/26 (abdominal pain) |
| Sun 1997 # | 6/11 (headache, nausea, dizzyness, abdominal pain, constipation) (loperamide oxide) | 3/11 |
| Phenylephrine gel versus placebo | ||
| Carapeti 2000a # | 3/36 (mild dermatitis after phenylephrine gel application, which settled when drug stopped) | 0/36 |
| Carapeti 2000b # | 0/12 | 0/12 |
| Cheetham 2001 # | 2/10 (burning sensation after phenylephrine gel application, which settled within minutes) | 0/10 |
| Park 2007 | Dermatitis reaction: 5/17; B = 1/12 Palpitation: 0/17; B = 1/12 Headache: 2/17; B = 0/12 | Dermatitis reaction: 1/12 Palpitation: 1/12 Headache: 0/12 |
| Sodium valproate versus placebo | ||
| Kusunoki 1990 # | 8/17 (abdominal pain and nausea) | 0/17 |
| Zinc aluminium ointment versus placebo ointment | ||
| Pinedo 2012 | 0/24 | 0/20 |