2.4. Analysis.

Comparison 2 ONE DRUG VERSUS ANOTHER DRUG OR A COMBINATIONOF DRUGS, Outcome 4 Different doses of oral loperamide.

Different doses of oral loperamide
Study	Outcome information	Significance
Stool frequency
Fox 2005 #	No effect
Stool consistency
Fox 2005 #	Trend for increased stool consistency from median (IQR) score 0.7 (0.5 to 0.9) with placebo to 0.4 (0.3 to 0.6) with 6 mg dose (0 = all hard, 1 = all liquid)
Faecal incontinence
Fox 2005 #	Less faecal spotting and incontinence with loperamide vs placebo	P < 0.05
Dose response for faecal incontinence
Fox 2005 #	Significant positive dose‐response relationship with increasing dose of loperamide (reduced FI with 2 mg dose, and almost no FI with 4 mg and 6 mg doses)
Adverse effects
Fox 2005 #	Adverse effects: none (specifically no severe constipation with the highest doses)