Number of people with adverse effects
Study	Drug	Placebo
Loperamide versus placebo
Read 1982 #	18/26 (constipation 11, diarrhoea 4, nausea and vomiting 3, abdominal pain 2)	1/26 (abdominal pain)
Sun 1997 #	6/11 (headache, nausea, dizzyness, abdominal pain, constipation) (loperamide oxide)	3/11
Phenylephrine gel versus placebo
Carapeti 2000a #	3/36 (mild dermatitis after phenylephrine gel application, which settled when drug stopped)	0/36
Carapeti 2000b #	0/12	0/12
Cheetham 2001 #	2/10 (burning sensation after phenylephrine gel application, which settled within minutes)	0/10
Park 2007	Dermatitis reaction: 5/17; B = 1/12 Palpitation: 0/17; B = 1/12 Headache: 2/17; B = 0/12	Dermatitis reaction: 1/12 Palpitation: 1/12 Headache: 0/12
Sodium valproate versus placebo
Kusunoki 1990 #	8/17 (abdominal pain and nausea)	0/17
Zinc aluminium ointment versus placebo ointment
Pinedo 2012	0/24	0/20