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. 2013 Jun 11;2013(6):CD002116. doi: 10.1002/14651858.CD002116.pub2
Whole‐gut transit time
Study Drug Placebo Significance
Loperamide versus placebo
Sun 1997 # N 11 mean 61 hours (SD 13)
 (loperamide oxide) N 11 mean 39 hours (SD 15) Significantly prolonged (P < 0.001) in patients taking loperamide oxide