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. 2020 Mar 2;75(4):1034–1044. doi: 10.1161/HYPERTENSIONAHA.119.14177

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© 2020 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Molecular heterogeneity of aldosterone-producing adenoma (APA). A, Example of aldosterone synthase (CYP11B2), 11β-hydroxylase (CYP11B1), GIRK4, and β-catenin staining in APA. B, Colocalization of CYP11B2, CYP17A1 (17α-hydroxylase), GIRK4 (G protein-activated inward rectifier potassium channel 4), and β-catenin by multiplex immunofluorescence in APA. C–F, Automatic quantification of colocalization of different proteins in 13 APAs carrying mutations in KCNJ5 (C; n=2), CACNA1D (D; n=5), ATP2B3 (E; n=3), and ATP1A1 (F; n=3). For each couple of colocalized proteins, marker 1 refers to the first marker indicated in the legend and marker 2 to the second one.