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. 2009 Oct 7;2009(4):CD002192. doi: 10.1002/14651858.CD002192.pub2

Mackenzie 1991.

Methods Anaesthetic drugs used: gallamine 20mg, propofol 2.5mg/kg, alfentanil 7microg/kg, suxamethonium 1mg/kg, N2O, O2 and enflurane 
 Premed‐induction interval: 72 (mean) 
 (minutes)
Participants 100
Interventions Drug(s) and dose: timolol 10mg/kg vs. placebo
Outcomes Critical flicker fusion threshold 15, 30, 60 and 120 mins after entering recovery area 
 Discharge
Notes 1) Preoperative effect demonstrated on multiple‐affect adjective check list 
 2) Difference from placebo? No. Many patients discharged within 2 hours
Risk of bias
Bias Authors' judgement Support for judgement
Adequate sequence generation? Unclear risk Method of randomization unknown
Allocation concealment? Unclear risk Unclear