Table 2.

Efficacy Analyses.^*

Outcome and Population	Levetiracetam (N = 145)	Fosphenytoin (N = 118)	Valproate (N = 121)
Primary efficacy outcome: cessation of seizures and improvement in consciousness at 60 min without other anticonvulsant medications
Intention-to-treat population
No. with outcome	68	53	56
Percent of patients with outcome (95% credible interval)	47 (39–55)	45 (36–54)	46 (38–55)
Probability that treatment is the most effective	0.41	0.24	0.35
Probability that treatment is the least effective	0.24	0.45	0.31
Per-protocol population
No. with outcome/total no.	51/109	37/79	43/91
Percent of patients with outcome (95% credible interval)	47 (38–56)	47 (36–58)	47 (37–57)
Probability that treatment is the most effective	0.31	0.34	0.36
Probability that treatment is the least effective	0.34	0.35	0.31
Adjudicated-outcomes population
No. with outcome	67	57	60
Percent with outcome (95% credible interval)	46 (38–54)	48 (39–57)	50 (41–58)
Probability that treatment is the most effective	0.17	0.35	0.48
Probability that treatment is the least effective	0.51	0.29	0.20
Secondary efficacy outcomes
Admission to ICU — no. (%)	87 (60.0)	70 (59.3)	71 (58.7)
Median length of ICU stay (IQR) — days	1 (0–3)	1 (0–3)	1 (0–3)
Median length of hospital stay (IQR) — days	3 (1–7)	3 (1–6)	3 (2–6)
Median time from start of trial-drug infusion to termination of seizures for patients with treatment success (IQR) — min†	10.5 (5.7–15.5)	11.7 (7.5–20.9)	7.0 (4.6–14.9)

^*ICU denotes intensive care unit.

^†Data were available for 14 patients in the levetiracetam group, 15 patients in the fosphenytoin group, and 10 patients in the valproate group.