Table 1. Evaluation of the anti-amastigote activity in Leishmania amazonensis and cytotoxicity with mouse peritoneal macrophages Swiss.
Compounds | IC50-AMA (μmoL L-1)* | CC50 (Peritoneal Macrophages) (μmoL L-1)* | IS |
---|---|---|---|
RP1 | 1.25±0.70 | >100±0.02 | 80 |
Fc-RP1 | 0.25±0.38 | 17.3±0.03 | 69 |
Ferrocene carboxylic acid | 4.4±0.91 | >100 ±0.03 | 22 |
Amphotericin B | 0.63±1.17 | 17.73±0.05 | 28 |
*Results are expressed by the mean of the duplicates plus the standard deviation.