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. 2020 Mar 26;15(3):e0229064. doi: 10.1371/journal.pone.0229064

Fig 7. Virulence assessed in a nonhuman primate model of necrotizing myositis.

Fig 7

Compared to the parental wild-type strain, deletion of Spy1336/R28 (ΔSpy1336) or Spy1337 (ΔSpy1337) significantly decreases (A) lesion volume, (B) CFU recovery, and (C) tissue destruction. Shown in panel C are representative microscopic images of the necrotic lesion centered at the GAS injection site (black box); hematoxylin and eosin stain, original magnification 4X. P = 0.05, Mann-Whitney Test. n = 3 NHPs/GAS strain.