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. 2020 Jan 30;5(2):e129531. doi: 10.1172/jci.insight.129531

Figure 5. Pathogenicity of each randomly selected SFTSV pure genotype (A, B-1, B-2) in ferrets.

Figure 5

Young adult (<2 years, n = 5; blue) or aged female and male ferrets (>4 years, n = 5; red) were inoculated with 105.0 FFU/mL of each randomly selected SFTSV strain (A) A, (B) B-1, and (C) B-2. Survival, viral titers in serum, and platelet concentration were assessed. The normal range of platelets (171.7 × 103/μL to 1280.6 × 103/μL) is marked by dashed lines in each panel. Both viral titers and platelet concentrations are presented as mean ± SEM. Pound sign (#) indicates no sample due to death of all ferrets of this group. Asterisks (*) indicate statistically significant difference between infected young adult and infected aged ferrets per dpi as determined by the Mantel-Cox method (survival) or 2-way ANOVA with Šidák’s comparison (viral copy number and platelets). Crosses (†) indicate significant difference in platelet count between noninfected aged adult and infected aged ferret as calculated by 2-way ANOVA with Tukey’s test. *P < 0.05, †P < 0.05, ††P < 0.001, ***P < 0.0001.