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. 2020 Jan 30;5(2):e132114. doi: 10.1172/jci.insight.132114

Figure 3. Implant-evoked photoreceptor degeneration induces localized BENAQ photosensitization of RGCs.

Figure 3

(A and C) MEA recordings from control and degenerated samples, measuring both native photoreceptor-elicited light responses (A) and BENAQ-mediated light responses (C). Flash intensity was 1.0 mW. (B and D) Each square represents an individual MEA electrode and its native (B) or BENAQ-mediated (D) light response. Color scale shows light response index (LRI) for the units recorded by each electrode. Black squares represent electrodes with very low frequency spike activity (<0.1 Hz) but no response to light. Gray squares represent electrodes with no detectable activity. (E) LRI of degenerated (n = 12) or control (n = 10) regions. *P < 0.05; 2-tailed t test. (F) Responses from degenerated retina comparing the LRI before and after treatment with BENAQ and then after blockade of synapses with neurotransmitter antagonists (n = 5). Values are mean ± SEM. *P < 0.05; paired t test.