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. 2020 Jan 30;5(2):e131437. doi: 10.1172/jci.insight.131437

Figure 2. Vaccine-induced Env-reactive long-lived memory B cells isolated from the RV144, RV305, and RV305a HIV-1 clinical trials.

Figure 2

MAbs isolated from vaccine recipients who volunteered for 2 or more clinical trials and confirmed by direct binding ELISA to be Env reactive were assessed for clonal relatedness with Cloanalyst (45). Additional clonal lineage members were identified by VH chain gene NGS. The boosting interval between RV144 and RV305 was 6 to 8 years and between RV305 and RV305a was 2 to 3 years.