Figure 3. Cardiomyocyte electrophysiologic properties after cardiac TRPV1 afferent depletion.

(A) Representative action potential (AP) tracing from untreated myocardial infarction (MI) and RTX-treated MI subjects (MI + RTX). (B–F) No differences were observed in resting membrane potential (B), AP amplitude (C), rate of AP rise (D), and APD₉₀ (E) and APD₅₀ (F). (G) Representative tracing of calcium (Ca²⁺) transients recorded from isolated border zone MI and MI + RTX cardiomyocytes. (H and I) There were no differences in time to peak Ca²⁺ fluorescence (H) and half maximal relaxation of the Ca²⁺ transient (τ₅₀) (I). n = 15 cells from 3 animals/group. Mann-Whitney U test (B–D), 2-way ANOVA (H and I) were used.