Skip to main content
. 2020 Feb 13;5(3):e131277. doi: 10.1172/jci.insight.131277

Figure 8. Blockade of IL-17A suppresses astrocyte activation in the hippocampus of CIE mice.

Figure 8

(A) One thousand twenty alcohol dependence–associated genes were identified in the hippocampus of CIE mice + IgG versus Air mice + IgG (P < 0.05). Heatmaps displaying the 25 most upregulated/downregulated genes. Expression of 25 alcohol dependence–associated genes that are most significantly upregulated/downregulated in the hippocampus of CIE mice in response to anti–IL-17A Ab treatment (vs. IgG). (B) Expression of GFAP and solute carrier family 1 member 3 (Slc1a3) (C) and activation markers of hippocampal astrocytes in alcohol-dependent CIE mice treated with IgG compared with nonaddicted mice or CIE mice treated with anti–IL-17A Ab compared with CIE mice treated with IgG. Log fold changes indicated by heatmap color.