Figure 6.

Treatments with EGF and/or hGly²GLP-2 increase crypt-villus growth abnormally in IE-IGF-1R KO mice. Male (n = 2–4) and female (n = 3–6) 6- to 10-week control and IE-IGF-1R KO mice were treated for 11 days with various combinations of vehicle, EGF, and/or hGly²GLP-2. (A) Jejunal villus height and crypt depth and (B) Proliferative index in the jejunal transit amplifying zone. All data were normalized by sex prior to combination within each treatment group to make n = 6–8. *P < 0.05, **P < 0.01, ***P < 0.001, # P < 0.05 as indicated.