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. 2020 Jan 31;39(13):2724–2740. doi: 10.1038/s41388-020-1178-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Volcano plot analysis of microarray showing that 1491 probes in the C1GALT1 knockdown AGS cells were significantly (p < 0.01) altered by twofold or more versus the control. Orange areas indicate significant changes in gene expression. b Functional map of differentially expressed genes. The over-representative GO terms of C1GALT1 knockdown AGS cells were mapped as networks. A node and each edge represent each enriched gene set (p < 0.05) and the gene overlap score between nodes passing a threshold (0.6), respectively. Node color encodes the enrichment p value (red: low; yellow: high). The node size is proportional to the number of genes belonging to the corresponding gene set. The edge thickness is proportional to the overlap score. Groups of functionally related gene sets are highlighted in colors and as labeled. c Quantitative RT-PCR validation of the microarray results. Results are the mean ± SD of three independent experiments. *p < 0.05; **p < 0.01 using Student’s t test.