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. 2020 Jan 4;39(1):161–171. doi: 10.1007/s10555-019-09841-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Age distribution and major subtypes of ALL. a Age distribution of ALL and AML in the USA from 1975 to 2016. Cases per 100,000 are shown. ALL has a clear peak at ages 1–4 and 5–9, whereas AML rates rise with age. b Major subtypes of ALL divided by age groups. The KMT2A-AFF1 fusion is very prevalent in infants, ETV6-RUNX1 and high hyperdiploidy (HD) dominate childhood ALL, and BCR-ABL1 is the most prevalent aberration in adults. Data for (a) taken from [1], data from (b) taken from [3]