Table 3.
In vitro effects of amino alcohols against E. multilocularis protoscoleces, cancer cells (A172 cells) and noncarcinogenic mammalian cells (Chang liver cells).
| Compounds | Structure | LC50 (μM) | Tox50 (μM) | |
|---|---|---|---|---|
| E. multilocularis PSC | A172 cell | Changliver cell | ||
| S1 |  |
20.45 ± 0.51 | ND | 43.98 ± 1.38 |
| S5 |  |
18.60 ± 1.00 | 11.98 ± 0.91 | 42.44 ± 0.34 |
| S6 |  |
16.99 ± 0.93 | 11.00 ± 5.00 | * |
| S11 |  |
18.65 ± 0.87 | 22.72 ± 1.37 | * |
| S16 |  |
17.35 ± 0.20 | 21.00 ± 6.24 | * |
| S19 |  |
18.84 ± 1.70 | 22.54 ± 1.79 | * |
| S28 |  |
19.89 ± 0.31 | 20.99 ± 4.12 | 35.41 ± 0.62 |
| S31 |  |
19.25 ± 0.80 | ND | 43.98 ± 1.38 |
| S39 |  |
17.65 ± 0.74 | ND | 51.46 ± 3.34 |
| S59 |  |
19.58 ± 0.56 | ND | 66.53 ± 2.99 |
*
The inhibition rates for compounds 6, 11, 16, and 19 were 24.65 ± 2.72%, 42.06 ± 1.78%, 34.56 ± 2.28%, and 36.51 ± 3.36% at 100 μM.