Table 4.
Pharmacokinetic parameters of S6, HT3 and BTB4 in the plasma of mice after oral (50 mg/kg) and intramuscular (12.5 mg/kg) administration.
| Parameters | S6 | BTB4 | HT3 | |||
|---|---|---|---|---|---|---|
| Oral (50mg/kg) | Intramuscular (12.5 mg/kg)a | Oral (50mg/kg) | Intramuscular (12.5mg/kg) | Oral (50mg/kg) | Intramuscular (12.5mg/kg) | |
| AUC(0–t)/ g/L*h | 5.10 ± 4.64 | - | 1692.29 ± 341.00 | 1589.90 ± 165.13 | 250.14 ± 32.49 | 191.91 ± 8.91 |
| MRT(0–t)/h | 4.34 ± 2.59 | - | 8.08 ± 1.55 | 16.02 ± 1.13 | 4.16 ± 0.85 | 18.12 ± 2.38 |
| Tmax/ h | 4.33 ± 3.51 | - | 2.00 ± 0.00 | 4.67 ± 3.06 | 0.33 ± 0.14 | 1.00 ± 0.00 |
| Cmax/ng*mL−1 | 1.55 ± 1.01 | - | 225.13 ± 55.37 | 86.39 ± 4.02 | 121.91 ± 42.63 | 39.59 ± 11.22 |
a
The drug concentration was below the detection limit, so the pharmacokinetics were not calculated.