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. 2020 Mar 20;11:383. doi: 10.3389/fmicb.2020.00383

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Copyright © 2020 Chen, Xie, Zhou, Zhang, Wu, Yang, Xu, Stedtfeld, Chen, Liu, Zhang, Xu and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Indicator species significantly (q < 0.1) associated with the disease progression. The bar indicates the relative abundance of each indicator species, while the size of each circle represents the indicator value (association strength) of a specific species with the different group: 0–0.25, not characteristic; 0.25–0.5, weakly characteristic; 0.5–0.75, characteristic; and 0.75–1.0, strongly characteristic. The color scheme for Healthy, HBVI, CHB and LC in the graph are red, green, blue, and purple.