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. 2020 Mar 20;11:383. doi: 10.3389/fmicb.2020.00383

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Copyright © 2020 Chen, Xie, Zhou, Zhang, Wu, Yang, Xu, Stedtfeld, Chen, Liu, Zhang, Xu and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The indicator species’ distribution and correlation with clinics along with the disease progression. (A) The correlation graph between clinics and indicator species, * denotes significance p < 0.05 and ** denotes p < 0.01. (B) The ROC curve based on the indicator OTU to predict its potential to distinguish healthy and non-healthy, HBVI and non-HBVI, CHB and non-CHB, LC and non-LC. (C) The distribution of those indicator species with higher abundance (>0.1%) that significantly correlated with clinics. * Denotes significance p < 0.05 and ** denotes p < 0.01. The color scheme for Healthy, HBVI, CHB and LC in the graph are red, green, blue, and purple.