. 2020 Mar 20;11:383. doi: 10.3389/fmicb.2020.00383

TABLE 1.

Baseline demographics and clinical characteristics.

	Healthy	HBVI	CHB	LC
Sample size	21	23	28	25
Sex (Male/Female)	16/5	16/7	19/9	20/5
Age	45.14 ± 9.03	43.83 ± 11.76	44.71 ± 11.3	51.24 ± 6.91
BMI (kg/cm²)	21.97 ± 2.91^ab	23.37 ± 3.93^a	23.21 ± 3.54^ab	21.87 ± 2.61^b
WBC count(10⁹/L)	6.06 ± 1.15^a	5.87 ± 1.48^a	5.48 ± 1.41^a	4.08 ± 1.92^b
RBC count(10¹²/L)	5 ± 0.46^a	4.55 ± 0.63^b	4.4 ± 0.68^b	3.92 ± 0.81^c
Hb(g/L)	150.05 ± 11.23^a	137.78 ± 21.62^ab	134.75 ± 21.96^b	115.52 ± 25.91^c
PLT count(10⁹/L)	235.68 ± 41.04^a	227.04 ± 55.87^ab	199.5 ± 55.77^b	84.76 ± 52.78^c
TP(g/L)	73.28 ± 4.78^a	68.82 ± 9.82^b	66.71 ± 5.63^b	67.36 ± 6.58^b
ALB(g/L)	48.87 ± 3.49^a	43.27 ± 7.4^b	38.51 ± 5.13^c	35.16 ± 5.24^d
GLO(g/L)	24.41 ± 3.99^a	25.55 ± 4.23^ab	28.2 ± 4.53^b	32.19 ± 6.06^c
ALB/GLO	2.06 ± 0.44^a	1.71 ± 0.31^b	1.4 ± 0.29^c	1.14 ± 0.29^d
TBIL(μmol/L)	7.7 ± 3.79^a	10.19 ± 3.81^a	51.44 ± 89.71^b	27.29 ± 15.46^ab
DBIL(μmol/L)	3.15 ± 1.24^a	3.95 ± 1.31^a	39.36 ± 77.11^a	13.13 ± 9.94^b
IBIL(μmol/L)	5.02 ± 2.53^a	8.66 ± 10.06^ab	12.07 ± 13.19^b	14.16 ± 9.59^b
ALT(U/L)	25.19 ± 17.03^a	36.95 ± 52.95^a	335.87 ± 409.82^b	46.56 ± 45.03^a
AST(U/L)	21.4 ± 7.19^a	26.38 ± 19.82^a	193.58 ± 256^b	70.69 ± 97.45^a
AST/ALT	0.99 ± 0.32^a	1.01 ± 0.51^a	0.78 ± 0.44^a	1.64 ± 1.05^b
GGT(U/L)	25.79 ± 11.62^a	26.48 ± 15.92^a	138.42 ± 145.18^b	86.54 ± 89.55^c
ALP(U/L)	60.91 ± 14.75	67.52 ± 19.66	114.42 ± 80.4	94.26 ± 45.13
BUN (mmol/L)	5.46 ± 1.57^a	4.89 ± 1.18^a	3.82 ± 1.18^b	5.02 ± 1.91^a
SCR(μmol/L)	75.67 ± 13.12^ab	79.7 ± 34.57^a	71.21 ± 17.68^b	71.46 ± 19.14^ab
BUN/SCR	0.07 ± 0.02^ab	3.98 ± 17.5^ab	0.05 ± 0.02^b	0.1 ± 0.13^a
BUA(μmol/L)	339.87 ± 92.81^a	339.65 ± 101.03^a	279.89 ± 67.44^b	301.94 ± 107.96^a
TG (mmol/L)	1.38 ± 0.81^a	1.12 ± 0.45^ab	1.26 ± 0.55^ab	0.98 ± 0.37^b
CHOL (mmol/L)	5.11 ± 0.87^a	4.72 ± 1.02^ab	4.3 ± 1.56^b	4.07 ± 1.56^b
HDL (mmol/L)	1.43 ± 0.36^a	1.35 ± 0.37^ab	1.39 ± 0.52^a	1.12 ± 0.29^b
LDL (mmol/L)	3.24 ± 0.77^a	3.2 ± 1.05^ab	2.91 ± 2.01^ab	2.65 ± 1.47^b
FBG (mmol/L)	5.45 ± 0.49^a	5.2 ± 1.18^ab	5.08 ± 1.35^ab	4.98 ± 1.52^b
HbsAg (IU/ml)	0 ± 0^a	7409.23 ± 17174.08^b	4624.51 ± 6123.07^ab	1585.75 ± 1326.34^a
HBV DNA (10⁷ IU/mL)	0 ± 0^a	1.77 ± 4.18^b	11.0 ± 25.7^b	0.42 ± 2.02^b

Letters indicate the ANOVA grouping among different HBV infection condition. Groups that do not share as common letter are significantly different. The four groups of patients according to clinical diagnosis included healthy, HBVI (chronic HBV carrier), CHB (chronic hepatitis B), and LC (liver cirrhosis) groups. WBC, white blood cell; RBC, red blood cell; Hb, hemoglobin; PLT, blood platelet; TP, total protein; ALB, albumin; GLO, globulin; ALB/GLO, albumin/globulin; TBIL, total bilirubin; DBIL, direct bilirubin; IBIL, indirect bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, glutamyl transpeptidase; ALP, alkaline phosphatase; BUN, blood urea nitrogen; SCR, serum creatinine; BUN/SCR, blood urea nitrogen/serum creatinine; BUA, blood uric acid; TG, triglyceride; CHOL, cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; and FBG, fasting blood glucose.