. 2020 Mar 20;10:362. doi: 10.3389/fonc.2020.00362

Table 2.

Univariate and multivariate analysis of prognostic factors for patients with non-small cell lung cancer.

Prognostic factor		No. of subjects	Univariate^a			Multivariate^b
			HR	95% CI	P-value	HR	95% CI	P-value
Total
Age	<65	290	1.00			1.00
	≥65	255	1.42	1.18–1.73	<0.001	1.23	1.00–1.52	0.052
Sex	Male	369	1.00			1.00
	Female	176	1.00	0.82–1.23	0.972	1.09	0.79–1.50	0.608
TNM Stage	I-II	76	1.00			1.00
	III	227	2.62	1.81–3.79		1.62	1.06–2.45	0.024
	IV	242	4.39	3.04–6.33	<0.001	2.31	1.45–3.68	<0.001
KPS score	≥80	324	1.00			1.00
	<80	221	1.85	1.52–2.25	<0.001	1.14	0.92–1.40	0.239
Lung lobectomy	Yes	164	1.00			1.00
	No	381	3.10	2.44–3.94	<0.001	1.93	1.42–2.63	<0.001
Chemotherapy	Yes	282	1.00			1.00
	No	263	1.63	1.34–1.98	<0.001	1.41	1.13–1.76	0.002
Radiotherapy	Yes	90	1.00			1.00
	No	455	1.31	1.01–1.70	0.044	1.04	0.78–1.38	0.811
Smoking	No	238	1.00			1.00
	Yes	307	0.98	0.81–1.20	0.870	1.20	0.88–1.63	0.239
Alcohol consumption	No	439	1.00			1.00
	Yes	106	1.04	0.82–1.32	0.757	1.07	0.82–1.38	0.622
Family history	No	508	1.00			1.00
	Yes	37	0.91	0.61–1.36	0.638	0.90	0.60–1.36	0.630
Hemoglobin	NPHb	432	1.00			1.00
	LPHb	122	1.82	1.45–2.27	<0.001	1.54	1.22–1.94	<0.001

For univariate analysis, Cox proportional-hazards model included survival time (<1 or ≥1 year) and one of the following factors: Age, sex, TNM stage, KPS score, lung lobectomy, chemotherapy, radiotherapy, smoking, alcohol consumption, family history or hemoglobin.

For multivariate analysis, Cox proportional-hazards model included survival time (<1 or ≥1 year), age, sex, TNM stage, KPS score, lung lobectomy, chemotherapy, radiotherapy, smoking, alcohol consumption, family history, and hemoglobin. HR, hazard ratio; CI, confidence interval; TNM, tumor-node-metastasis; KPS, Karnofsky performance status; NPHb, normal pretreatment hemoglobin (men, 120–160 g/L; women 110–150 g/L); LPHb, low pretreatment hemoglobin (men, <120 g/L; women, ≤110 g/L).