Table 2.
Longitudinal progression of ADNI cohort.
| Disease stage at visit 1 | AD | MCI | CN | |||
|---|---|---|---|---|---|---|
| Visit 1 (n = 213) | Visit 2 (n = 384) | Visit 1 (n = 322) | Visit 2 (n = 183) | Visit 1 (n = 322) | Visit 2 (n = 277) | |
| FDG-PET (mean (s.d)) | 1.07 (0.14) | 1.01 (0.16) | 1.2 (0.12) | 1.12 (0.16) | 1.31 (0.11) | 1.26 (0.14) |
| CDR-SB | 4.37 (1.59) | 6.57 (2.94) | 1.55 (0.86) | 4.26 (3.71) | 0.03 (0.12) | 0.5 (1.39) |
| RAVLT immediate | 23.25 (7.18) | 18.68 (8.26) | 31.09 (9.22) | 25.32 (12.27) | 44.7 (9.72) | 42.85 (12.06) |
| RAVLT learning | 1.72 (1.77) | 1.49 (1.69) | 3.33 (2.36) | 2.62 (2.29) | 5.91 (2.3) | 5.17 (2.65) |
| RAVLT forgetting | 4.49 (1.72) | 4.08 (2.06) | 4.59 (2.2) | 4.05 (2.29) | 3.71 (2.79) | 3.72 (2.81) |
| LDEL total | 1.26 (1.79) | 0.84 (2.04) | 3.93 (2.74) | 3.92 (4.89) | 13.34 (3.26) | 13.29 (4.89) |
| DIGIT score | 27.9 (12.31) | 22.81 (14.32) | 37.69 (11.12) | 32.46 (13.61) | 45.96 (10.66) | 44.86 (12.87) |
| Trail B score | 192.36 (85.21) | 220.58 (89.18) | 125.94 (72.44) | 165.53 (104.62) | 85.04 (42.99) | 95.93 (55.52) |
| Ventricles, | 46499.51 (22953.63) | 52370.72 (24362.76) | 42051.86 (21748.35) | 52551.46 (25301.08) | 33541.74 (16974.45) | 40761.95 (19629.52) |
| Hippocampus, | 5635.56 (986.56) | 5300.64 (1068.79) | 6390.79 (1086.61) | 5776.29 (1175.13) | 7351.41 (869.71) | 6914.75 (983.24) |
| Whole Brain, | 965948.3 (115387.73) | 936315.7 (113321.24) | 996207.8 (105351.95) | 956487.3 (105646.97) | 1024226 (105334.28) | 992703.1 (108390) |
| Entorhinal, | 2786.12 (681.65) | 2558.33 (679.19) | 3309.26 (752.82) | 2985.22 (799.2) | 3800.91 (639.1) | 3625.8 (684.76) |
| Fusiform, | 15238.1 (2610.82) | 14286.5 (2717.05) | 16438.82 (2328.43) | 15392.79 (2541.99) | 17652.72 (2404.69) | 17039.53 (2595.64) |
| Mid Temp, | 16940.57 (3086.25) | 15700.37 (3152.04) | 18693.25 (2927.51) | 16960.81 (3347.8) | 20089.13 (2672.98) | 19203.15 (2848.84) |
| ICV, | 1532939 (175896.59) | 1534174 (174868.9) | 1572611 (163710.12) | 1579756 (172889.54) | 1524544 (154553.21) | 1528301 (161108.2) |
| Amyloid beta, pg/ml | 672.9 (310.61) | 526.76 (182.85) | 835.05 (419.06) | 710.51 (409.3) | 1187.06 (448.89) | 1188.7 (448.57) |
| Tau, pg/ml | 369.25 (138.03) | 388.98 (161.34) | 314.67 (115.32) | 324.83 (133.22) | 236.01 (91.05) | 256.7 (102.02) |
| P-Tau, pg/ml | 36.85 (15.23) | 39.34 (18.43) | 31.18 (13.3) | 31.14 (15.63) | 21.77 (9.37) | 23.84 (10.82) |
Abbreviations: FDG-PET = F-fluorodeoxyglucose positron emission tomography. CDR-SB = Clinical dementia rating–sum of boxes. RAVLT = Rey auditory verbal learning test. LDEL = Logical memory delayed. DIGIT = Digit Symbol Substitution Test. ICV = Intracranial volume. P-Tau = Phosphorylated Tau.