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. 2020 Mar 27;5:23. doi: 10.1038/s41392-020-0105-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Sequence base pairing between circFASN and miR-33a-5p. The seed region is fully complementary to the sequence of circFASN. b Relative expression of predicted miR-33a-targeting circRNAs in Hep-G2 cells detected by qPCR. c circFASN could only be amplified by random primers. d circFASN is resistant to RNase R treatment. e The luciferase reporter assay indicated that circFASN directly interacts with miR-33a-5p at the predicted interaction site in human cells. f miR-33a expression increased after the silencing of circFASN in Hep-G2 cells. Data represent the mean ± SD. *P < 0.05, **P < 0.01, NS, not significant. The experiments were independently repeated at least three times.