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. 2020 Mar 26;10:5515. doi: 10.1038/s41598-020-62240-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of live imaging data from the FLG-KD epidermal model. (a) A graph of the time taken for morphological change to occur in the control (siNC) (n = 35) and FLG-KD models (siFLG) (n = 32). Wilcoxon rank sum test: p = 1.5 × 10⁻¹⁰. (b) A graph of the average times from the start of morphological change to expansion (shown as “Expansion”) and from expansion to flattening (shown as “Flattening”) in the control (n = 28) and FLG-KD (n = 22) models. The cells that underwent a morphological change, expansion, and flattening during observation were counted. Wilcoxon rank sum test: p = 0.18 (Expansion), p = 2.2 × 10⁻¹² (Flattening). Details are shown in Supplementary Fig. 6. (c) A graph of the number of cells that began to undergo a morphological change per hour in the control and FLG-KD models (7 (control) and 8 (FLG-KD) independent experiments). Wilcoxon rank sum test: p = 0.014. p values, *<0.05, **<0.01, ***<0.001.