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. 2020 Mar 26;11:1570. doi: 10.1038/s41467-020-15352-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic of STN opto-inhibition using CamKII or a ubiquitous and neuron-specific promotor: the human synapsin 1 (hSyn) dependent virus in 6-OHDA rats. b, c Sagittal epifluorescence images (top) showing the EYFP expression in STN and the appropriate axonal labeling in GP and substantia nigra pars reticulata (SNr). Bottom traces show examples of STN neuron opto-inhibition in CamKII-STN (b) or hSyn-STN (c) conditions (slice orientation: dorso-rostral, scale: 400 µm, scales: 0.5 mV, 6 s recording). d Proportion of STN neurons inhibited (black), excited (blue), or non-modulated (white) by the laser stimulation in CamKII-STN and hSyn-STN. e Population PSTH of STN firing during opto-inhibition in CamKII-STN (bin: 50 ms) and hSyn-STN groups (bin: 50 ms). f Mean normalized power spectrum of mCx ECoG (analysis on the best β epochs recordings) during OFF and ON laser stimulations in CamKII-STN (left) and hSyn-STN (right). g Example of peri-event spectrogram of mCx ECoG recording during STN opto-inhibition in hSyn-STN rat. h Cumulative distribution function of the β-AUCs differences calculated for AUC_(Pre–OFF) versus AUC_(OFF–ON) for all ECoG β epochs in CamKII-STN (top) and hSyn-STN (bottom) conditions. i Mean coherence for ECoG versus GP LFP at β-frequency during OFF and ON laser stimulation in hSyn-STN rats. Group data are mean ± SEM. See also Supplementary Table 2 for statistical information.