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. 2020 Mar 20;11:415. doi: 10.3389/fimmu.2020.00415

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Copyright © 2020 Deal, Thauland, Stiehm, Garcia-Lloret and Butte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) IL-2, IL-4, and IL-21 stimulation in CD4⁺ T cells in control, sister (donor) and patient, as measured by pSTAT5, pSTAT6, and pSTAT3, respectively. (B) IL-4 and IL-21 stimulation of B cells in control, sister (donor), and patient as measured by pSTAT6 and pSTAT3. (C) IL-2 and IL-15 stimulation in NK cells in control and patient as measured by pSTAT5. (D) IL-4 stimulation in CD14⁺ monocytes in control and patient as measured by pSTAT6.