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. 2020 Mar 26;10:5504. doi: 10.1038/s41598-020-62145-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of ETNPPL in gliomas. (A) WB detection of ETNPPL in proteins extracted from indicated gliomas. ETNPPL is detected as a single band with the predicted size (55 kDa). The uncropped image of the WB is presented on Supplemental Fig. 8A. Oligo II: grade II oligodendrogliomas, Astro II and III: grade II and III astrocytomas. GBM: IDH1 non-mutated glioblastomas. β-actin detection was used for normalization. Quantification for ETNPPL is presented on the right-hand side panel (4 astrocytomas IDH1 R132H-mutated and 6 glioblastomas). Test = Mann-Whitney test (**p = 0.01). (B) Immunohistochemistry for ETNPPL (brown) in one IDH1-mutated diffuse grade II astrocytoma. The protein is present either in the nucleus (red arrow) or in the cytoplasm (black arrow) of cells. Scale bars = 150 μm. Nuclei are stained with hematoxylin.