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. 2020 Mar 26;10:5507. doi: 10.1038/s41598-020-62319-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Simplified scheme of the cerebral metabolism of HP [1-¹³C] lactate. (b) Dynamic ¹³C MRS spectra measured in the head of an MCAO mouse following the injection of HP [1-¹³C] lactate (183.5 ppm). The transfer of the label to [1-¹³C] pyruvate at 171.5 ppm can be readily detected. In the sum of the spectra shown in the top panel (red), the peak of ¹³C bicarbonate becomes visible at 161.5 ppm. The peak designated by (*) at 176 ppm results from chemical impurities that overlap with the expected [1-¹³C] alanine peak.