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. 2020 Mar 26;10:5507. doi: 10.1038/s41598-020-62319-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a,c) Pyruvate-to-lactate ratios (PLR) and ratios corrected for [1-¹³C] lactate concentration in blood at the time of injection (cPLR), overlaid with individual data points. One-way ANOVA test indicates significant statistical difference (p < 0.05) between both PLR and cPLR 1 h post-reperfusion (red) and sham (black) and 2 h post-reperfusion (blue). The average values for cPLR were 0.46 ± 0.21, 0.17 ± 0.12 and 0.14 ± 0.07 in MCAO mice 1 h and 2 h post-reperfusion and sham respectively. (b,d) Bicarbonate-to-lactate ratios (BLR) and ratios corrected for [1-¹³C] lactate concentration in blood at the time of injection (cBLR) overlaid with individual data points showing a trend for increased BLR and cBLR in MCAO mice 1 h (red) and 2 h post-reperfusion (blue) compared to sham (black). The average values for cBLR were 0.058 ± 0.018, 0.057 ± 0.015 and 0.031 ± 0.027 in MCAO mice 1 h and 2 h post-reperfusion and sham respectively.