Table 1.

Neurochemical profiles in the striatum of sham operated mice and after 30 min of transient ischaemia.

metabolites	Sham (3)	~ 1-h (3)	Changes at ~1-h	~2-h (3)	Changes at ~2-h
Ala	2.0 ± 0.5	2.3 ± 0.3		2.6 ± 0.5
Cr	4.5 ± 0.2	4.5 ± 0.2		4.2 ± 0.3
PCr	4.3 ± 0.2	2.9 ± 0.5	↓ **	2.9 ± 0.4	↓ **
Cr+PCr	8.8 ± 0.3	7.4 ± 0.5	↓ *	7.2 ± 0.6	↓ **
PCr/Cr	0.95 ± 0.06	0.64 ± 0.12	↓ **	0.70 ± 0.07	↓ *
GABA	2.3 ± 0.2	3.4 ± 0.1	↑ **	3.2 ± 0.5	↑ *
Gln	3.1 ± 0.3	3.1 ± 0.3		3.0 ± 0.6
Glu	7.0 ± 0.3	4.8 ± 0.6	↓ ***	4.2 ± 0.2	↓ ****
Glu+Gln	10.1 ± 0.4	8.0 ± 0.9	↓ *	7.2 ± 0.7	↓ ***
Gln/Glu	0.44 ± 0.04	0.65 ± 0.01	↑ p = 0.06	0.70 ± 0.15	↑ *
GSH	1.5 ± 0.3	1.3 ± 0.5		0.9 ± 0.3
Gly	1.6 ± 0.3	2.4 ± 0.5		2.2 ± 0.4
myo-Ins	5.9 ± 0.3	5.0 ± 0.6		4.3 ± 0.8	↓ *
Myo-Ino + Gly	7.4 ± 0.3	7.4 ± 0.1		6.5 ± 0.7	↓ p = 0.08
Lac	7.0 ± 0.8	29.2 ± 6.9	↑ ***	28.9 ± 6.8	↑ ***
NAA	6.7 ± 0.4	4.1 ± 0.4	↓ ****	3.8 ± 0.5	↓ ****
NAA + NAAG	6.9 ± 0.4	4.1 ± 0.3	↓ ****	3.9 ± 0.5	↓ ****
Tau	14.0 ± 1.9	11.6 ± 1.9		9.8 ± 2.3
PE	2.9 ± 0.6	1.5 ± 0.2	↓ *	1.3 ± 0.4	↓ **
Mac	1.9 ± 0.1	1.2 ± 0.1	↓ ***	1.2 ± 0.1	↓ ****
GPC + PCho	1.10 ± 0.04	1.12 ± 0.18		1.03 ± 0.25

Ala, alanine; Cr, creatine, PCr, phosphocreatine; GABA, γ-aminobutyric acid; Gln, glutamine; Glu, glutamate; GSH, glutathione; Gly, glycine; myo-Ins, myo-inositol; Lac, lactate; NAA, N-acetyl-aspartate; NAAG, N-acetyl-aspartate-glutamate; Tau, taurine; PE, phosphatidylethanolamine; Mac, macromolecule; GPC, glycerophosphocholine; PCho, phosphocholine. All concentrations, except ratios, are in mmol/kg. Number of animals is indicated in parentheses. Only metabolites  with CRLB of less than 45% in all animals are presented. The changes are calculated compared to sham and displayed with specific oriented arrows (‘↓’ as decrease and ‘↑’ as increase). The number of ‘*’ represent statistically significant levels of p = 0.05, 0.02, 0.01 and 0.001.