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. 2020 Mar 26;10:5546. doi: 10.1038/s41598-020-62468-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IRS4^PVH neuron activity is dispensable for melanocortin agonist-mediated satiety. In situ hybridization for Irs4 (A, blue) and Mc4r (A, red) mRNA in the PVH of adult wildtype mice. Melanocortin agonist-induced satiety was tested in mice with IRS4^PVH neuronal silencing (B,C). Two-hour (B) and four-hour (C) feeding was significantly decreased following i.p. injection of the MC4R agonist MT-II (150 ug/mouse) in all cohorts of mice, despite the silencing of IRS4^PVH neurons in the PVH^TetTox group. Average values ± SEM are shown, **p < 0.01, ***p < 0.001, ****p < 0.0001; PVH^TetTox n = 6, PVH^Flex n = 17, WT^TetTox n = 13. Significance was determined using a paired t-test between vehicle and MTII injected mice within the same cohort. Dashed boxes (A^I, A^II) indicate regions cropped and digitally enlarged.