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Characteristics of NPs
| Null-NPs | NP-BEZ235 | NP-BEZ235-Ab | |
|---|---|---|---|
| Diameter (nM) | 92.0 ± 15.1 | 107.0 ± 16.5 | 115.0 ± 18.3 |
| ZP (mV) | − 18.1 ± 3.9 | − 15.7 ± 3.13 | − 12.2 ± 2.37 |
| PDI | 0.16 ± 0.08 | 0.19 ± 0.10 | 0.21 ± 0.15 |
| LC (%) | N/A | 11.2 ± 0.9 | 10.0 ± 0.7 |
| EE (%) | N/A | 63.1 ± 1.1 | 57.6 ± 2.5 |
Values are mean ± standard deviation (n = 3)
Abbreviations: NPs PLGA-PEG NPs, ZP zeta potential, PDI polydispersity index, LC loading content, EE encapsulation efficiency
