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. 2020 Mar 20;11:381. doi: 10.3389/fmicb.2020.00381

FIGURE 1.

FIGURE 1

Outcomes of the mini-CRISPR array-mediated virus arms race as a function of the coinfection probabilities experienced by each virus. Depending on the relative ordering of the critical thresholds P∗ and P∗∗, three qualitatively different cases exist (A–C). The presence of a mini-CRISPR array in a virus is denoted by black borders and a directed arrow pointing to the other virus. Mutual targeting is indicated by bidirectional arrows. In panels (A) and (B) the central region correspond to a bistable state in which two outcomes are possible. The central region in panel (C) corresponds to a state of cyclic polymorphism involving subpopulations with and without mini-CRISPR arrays. An example of such cyclic dynamics is shown in panel (D). Parameter values in panel (D) are c = 0.1, wA = 0.8, wB = 0.5, qA = 0.5, qB = 0.2, pB|A = 0.2, pA|B = 0.3.