Table 2.
Time, min | 2-DG + ACSF | 2-DG + 5-HT2A | 2-DG + 5-HT7 | 2-DG/cC + 5-HT7 |
---|---|---|---|---|
Baseline | 43.9 ± 3.4 | 40.8 ± 1.7 | 43.0 ± 3.8 | 43.0 ± 2.9 |
30 | 43.7 ± 4.2 | 40.4 ± 2.1 | 43.8 ± 3.3 | 43.4 ± 3.4 |
60 | 44.6 ± 3.0 | 42.8 ± 1.3 | 43.0 ± 3.2 | 43.8 ± 3.2 |
90 | 44.8 ± 3.4 | 40.7 ± 1.3 | 43.5 ± 3.0 | 43.3 ± 3.7 |
Baseline | 314 ± 20 | 304 ± 36 | 311 ± 27 | 319 ± 20 |
30 | 302 ± 21 | 280 ± 58 | 296 ± 23 | 319 ± 21 |
60 | 298 ± 42 | 282 ± 53 | 292 ± 31 | 312 ± 20 |
90 | 304 ± 29 | 267 ± 42 | 292 ± 35 | 305 ± 18 |
MAP, mmHg | ||||
Baseline | 138 ± 8 | 127 ± 28 | 122 ± 18 | 124 ± 10 |
30 | 136 ± 12 | 129 ± 25 | 118 ± 20 | 117 ± 13 |
60 | 135 ± 14 | 130 ± 24 | 120 ± 19 | 116 ± 15 |
90 | 133 ± 23 | 127 ± 24 | 119 ± 19 | 108 ± 17 |
pH | ||||
Baseline | 7.38 ± 0.02 | 7.41 ± 0.03 | 7.39 ± 0.03 | 7.39 ± 0.03 |
30 | 7.38 ± 0.04 | 7.41 ± 0.02 | 7.40 ± 0.02 | 7.40 ± 0.03 |
60 | 7.38 ± 0.03 | 7.41 ± 0.02 | 7.40 ± 0.02 | 7.39 ± 0.04 |
90 | 7.38 ± 0.02 | 7.39 ± 0.05 | 7.43 ± 0.13 | 7.39 ± 0.03 |
sBE | ||||
Baseline | 0.7 ± 1.1 | 1.3 ± 1.5 | 1.1 ± 1.1 | 1.2 ± 1.8 |
30 | 0.8 ± 1.8 | 0.9 ± 1.9 | 2.3 ± 1.0 | 1.9 ± 0.9 |
60 | 1.0 ± 1.3 | 1.7 ± 1.7 | 1.6 ± 1.0 | 1.8 ± 1.5 |
90 | 0.9 ± 1.5 | 0.6 ± 1.6 | 1.1 ± 1.4 | 1.2 ± 1.5 |
Temperature, °C | ||||
Baseline | 37.9 ± 0.3 | 37.3 ± 0.5 | 37.4 ± 0.4 | 37.5 ± 0.5 |
30 | 38.0 ± 0.4 | 37.4 ± 0.6 | 37.4 ± 0.4 | 37.2 ± 0.5 |
60 | 37.9 ± 0.6 | 37.4 ± 0.4 | 37.5 ± 0.4 | 37.1 ± 0.5 |
90 | 38.0 ± 0.6 | 37.3 ± 0.4 | 37.5 ± 0.4 | 37.2 ± 0.6 |
2-DG, 2-deoxyglucose; cC, compound C; ACSF, artificial cerebrospinal fluid; 5-HT2A, serotonin type 2A receptor; 5-HT7, serotonin 7 receptor; MAP, mean arterial pressure; sBE, standard base excess.