Table 3.

Physiological variables at baseline and 30, 60, and 90 min after last it injection

Time, min	Met (2.5 mM) + ACSF	Met (2.5 mM) + 5-HT2A	Met (2.5 mM) + 5-HT7	Met (2.5 mM)/cC + 5-HT7
$\text{P}{\text{a}}_{\text{C}\text{O}}{}_{{}_2}$
Baseline	45.6 ± 7.0	41.5 ± 3.0	44.0 ± 2.0	45.8 ± 1.3
30	45.4 ± 6.6	42.1 ± 2.2	44.5 ± 2.2	45.9 ± 1.5
60	45.2 ± 6.7	41.4 ± 1.6	44.1 ± 2.5	46.8 ± 1.5
90	45.6 ± 6.4	41.1 ± 3.8	43.7 ± 1.8	46.0 ± 1.4
$\text{P}{\text{a}}_{\text{O}}{}_{{}_2}$
Baseline	300 ± 54	300 ± 23	310 ± 26	310 ± 25
30	298 ± 37	297 ± 19	315 ± 12	301 ± 21
60	292 ± 34	288 ± 21	304 ± 17	293 ± 18
90	295 ± 34	284 ± 24	302 ± 13	282 ± 20
MAP, mmHg
Baseline	129 ± 21	122 ± 10	129 ± 25	131 ± 16
30	128 ± 19	132 ± 12	123 ± 25	126 ± 14
60	128 ± 23	137 ± 14	119 ± 20	123 ± 17
90	131 ± 21	134 ± 13	114 ± 15	119 ± 12
pH
Baseline	7.36 ± 0.05	7.40 ± 0.02	7.38 ± 0.02	7.37 ± 0.03
30	7.37 ± 0.04	7.41 ± 0.05	7.39 ± 0.03	7.37 ± 0.03
60	7.38 ± 0.05	7.42 ± 0.06	7.38 ± 0.02	7.37 ± 0.02
90	7.37 ± 0.04	7.41 ± 0.07	7.39 ± 0.01	7.36 ± 0.02
sBE
Baseline	0.2 ± 1.6	0.6 ± 1.6	0.8 ± 1.5	1.2 ± 2.0
30	1.1 ± 1.8	2.6 ± 5.2	2.1 ± 1.4	0.9 ± 1.9
60	1.0 ± 1.4	2.5 ± 4.0	1.3 ± 1.1	1.8 ± 1.3
90	1.0 ± 0.9	1.0 ± 3.3	1.3 ± 0.9	0.6 ± 1.3
Temperature, °C
Baseline	37.4 ± 0.7	37.7 ± 0.8	37.4 ± 0.5	37.7 ± 0.4
30	37.8 ± 0.4	37.3 ± 0.5	37.4 ± 0.5	37.6 ± 0.4
60	38.1 ± 0.6	37.3 ± 0.4	37.7 ± 0.1	37.6 ± 0.5
90	38.0 ± 0.6	37.5 ± 0.7	37.4 ± 0.3	37.6 ± 0.5

Met, metformin; cC, compound C; ACSF, artificial cerebrospinal fluid; 5-HT_2A, serotonin type 2A receptor; 5-HT₇, serotonin 7 receptor; MAP, mean arterial pressure; sBE, standard base excess.